JOB OFFERS MEETINGS 2017 in France
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JOB OFFERS ****************** MEETINGS 2017 in France ******************
ASSISTANT PROFESSOR
Position
available
for
an
Assistant-‐Professor
in
Vascular
Biology
at
University
Grenoble-‐Alpes
(France)
Specifications
of
the
position:
Young
researcher
keen
on
innovative
in
vivo
technologies
for
the
study
of
blood
and/or
lymphatic
vessel
development
Teaching
duties:
Physiology
(animal
experimentation,
genetically
engineered
mouse
models
for
biological
research)
License
and
Master
students
Research
duties:
Development
of
a
personal
research
program
on
vascular
biology
in
the
Team
«
BMPs
in
angiogenesis
and
lymphangiogenesis
»
headed
by
Dr
Sabine
Bailly.
Within
the
Grenoble
Institute
for
Biosciences
and
Biotechnologies
(BIG,
300
fellows),
the
Laboratory
Biology
of
Cancer
and
Infection
(BCI,
UMR_S
1036,
INSERM-‐UGA-‐CEA),
headed
by
Dr
Jean-‐Jacques
Feige,
is
a
research
lab
(around
60
people)
that
has
a
strong
international
recognition
in
the
field
of
vascular
biology.
The
laboratory
studies
the
developmental
formation
of
new
vessels
(angiogenesis
and
lymphangiogenesis)
as
well
as
the
cellular
interactions
of
bacteria
and
metastatic
tumor
cells
with
the
vasculature.
It
uses
molecular
and
cellular
techniques
and
aims
at
integrating
its
pathophysiological
observations
in
various
murine
models
of
human
pathologies.
The
lab
is
associated
with
IDEX
“Université
Grenoble-‐Alpes
:
Université
de
l'Innovation“
and
LABEX
GRAL
(Grenoble
Alliance
for
Integrated
Structural
and
Cell
Biology),
two
local
scientific
networks
supported
by
University
Grenoble-‐Alpes
(UGA).
In
the
BIG
Institute,
members
of
the
lab
have
access
to
several
highly
efficient
technological
platforms:
SPF
mouse
facility
equipped
with
bioluminescence/fluorescence
imagers,
mass
spectrometry
and
high-‐content
screening
platforms,
high
resolution
optical
microscopy,
last
generation
FACS.
The
BCI
laboratory
wants
to
hire
a
young
Assistant
Professor
(Maître
de
Conférences)
who
will
benefit
from
a
«
Chaire
Mixte
INSERM
»
for
5
years.
This
implies
that
teaching
schedule
is
limited
to
one-‐third
of
normal
duty
for
the
initial
five
years.
The
Assistant
professor
will
perform
his
research
in
the
team
headed
by
Dr
Sabine
Bailly
and
will
develop
his
own
program
in
interaction
with
the
team’s
research
interests.
This
team
currently
studies
the
role
of
BMP9/ALK1
signaling
pathway
in
blood
and
lymphatic
vessel
development
and
aims
at
developing
innovative
targeted
therapeutic
strategies
for
the
treatment
of
cancer
and
several
hereditary
vascular
diseases
(Hereditary
Hemorrhagic
Telangiectasia,
Pulmonary
Arterial
Hypertension).
The
candidate
should
have
a
PhD
degree
in
biological
sciences
and
a
successful
post-‐doctoral
experience
in
vascular
biology.
He
should
have
experience
in
cellular
signaling
and
in
murine
models
of
vascular
diseases
or
dysfunctions
(conditional
tissue-‐specific
gene
knock-‐outs,
transgenic
animals
expressing
lineage-‐specific
fluorescent
markers,
tumor
models,
or
other).
An
experience
in
“omic“
analyses
on
small
size
biological
samples
or
in
in
vivo
imaging
would
be
appreciated
as
well
as
scientific
knowledge
of
vascular
pathologies.
Contacts:
Dr.
Jean-‐Jacques
Feige,
Head
of
BCI
Laboratory,
jean-‐jacques.feige@cea.fr
Dr.
Sabine
Bailly,
Head
of
the
BCI/BAL
team,
sabine.bailly@cea.fr
Laboratoire
Biologie
du
Cancer
et
de
l'Infection
Unité
Mixte
de
Recherche
INSERM-‐CEA-‐UGA-‐CNRS
U1036
Institut
de
Biosciences
et
Biotechnologies
de
Grenoble
tél.
(33)
04
38
78
47
27
Fax.
(33)
04
38
78
50
58
Website
:
http://www.cea.fr/drf/big/BCI
Proposition de chaire mixte INSERM-‐UGA CNU : section 65 ou 66 CSS 3 – Physiologie et physiopathologie des grands systèmes CSS 2 – Pathologie du développement, hématologie et cancérologie Argumentaire pour la proposition de chaire mixte INSERM-‐UGA dans l’unité 1036-‐Equipe BAL Profil : Technologies innovantes pour l’étude in vivo du développement des vaisseaux sanguins et lymphatiques Au sein de l’Institut de Biosciences et Biotechnologies de Grenoble (BIG, 300 personnes), le laboratoire de Biologie du Cancer et de l’Infection (BCI, UMR_S 1036, INSERM-‐UGA-‐CEA), dirigé par Jean-‐Jacques Feige, est une Unité de recherche d’environ 60 personnes, organisée en 3 équipes de recherche, avec un positionnement international fort dans l’étude des vaisseaux sanguins au cours du développement, de l’invasion tumorale et de l’infection bactérienne. Le laboratoire met en jeu des approches moléculaires et cellulaires et vise à intégrer ses observations physiopathologiques en utilisant des modèles murins de diverses pathologies. Le laboratoire BCI/U1036 est membre de l’IDEX grenoblois “Université Grenoble-‐ Alpes : Université de l'Innovation“ et du LABEX GRAL (Grenoble Alliance for Integrated Structural and Cell Biology). L’Institut BIG dispose de plateaux technologiques performants : Animalerie EOPS équipée d’imageurs de bioluminescence/fluorescence, plateformes IBISA de protéomique et de criblage HTS de chimiothèques, plateforme de microscopie optique haute résolution µLife, FACS de dernière génération. La chaire mixte INSERM-‐UGA est proposée pour recruter un(e) jeune maitre de conférences au sein de l’équipe du Dr Sabine Bailly dans le but de renforcer cette équipe de recherche et d'augmenter sa compétitivité au niveau international dans le domaine de la vascularisation sanguine et lymphatique. La thématique scientifique de l'équipe est l'étude d’une voie de signalisation (voie des bone morphogenetic proteins BMP9/10 et de leur récepteur ALK1) dans le développement des vaisseaux sanguins et lymphatiques afin de proposer de nouvelles approches thérapeutiques ciblées dans les pathologies vasculaires et la cancer. Pour cela, l’équipe développe 3 axes de recherches: -‐ Étude des rôles respectifs de BMP9 et BMP10 dans le développement sanguin et lymphatique -‐ Étude de l'implication de BMP9 et BMP10 dans deux pathologies vasculaires : la maladie de Rendu-‐Osler encore appelée HHT pour (Télangiectasie Hémorragique Héréditaire) et l'hypertension artérielle pulmonaire -‐ Étude de l'implication de BMP9 et BMP10 dans le développement tumoral et la dissémination métastatique : ALK1 comme cible thérapeutique. Le(la) candidat(e) au poste de Maitre de Conférences aura effectué une thèse et un stage postdoctoral en biologie cellulaire et moléculaire avec utilisation de modèles murins dans le domaine vasculaire. Il/elle possèdera une expertise forte en signalisation cellulaire ainsi qu'une très bonne expertise dans la manipulation de modèles murins (souris invalidées de façon conditionnelle et tissu-‐spécifique, souris exprimant des marqueurs fluorescents lignage-‐spécifiques, modèles tumoraux). Une expérience des analyses “omiques“ à partir de petits échantillons biologiques ou d’imagerie du petit animal serait appréciée. Des connaissances sur les pathologies vasculaires sanguines ou lymphatiques seraient également un atout pour ce poste. Le titulaire de la chaire aura pour mission de développer un axe de recherche dans le cadre de la thématique de l’équipe du Dr Sabine Bailly. Elle/Il cherchera à mettre en place de nouveaux modèles murins génétiquement modifiés pour étudier les processus moléculaires et cellulaires conduisant au remodelage des vaisseaux sanguins et lymphatiques. Elle/Il développera au sein de l'équipe, et en relation avec d’autres équipes du Laboratoire BCI et de l’Institut BIG, de nouvelles approches innovantes pour étudier le développement vasculaire.
JUNIOR POSITION
Opening of the HEARING INSTITUTE in the heart of PARIS
Group Leader positions
The Hearing Institute, an auditory neuroscience research institute, aims to advance
our knowledge of auditory signal processing from the sensory organ to the brain,
auditory perception and cognition, multisensory and sensorimotor integration, in
healthy and pathological conditions. It will do this by bringing together teams of
scientists from diverse fields, ranging from biophysics, acoustics, neurobiology,
molecular and cellular biology, and genetics, to bioinformatics and computational
neuroscience, all highly committed to interdisciplinary research. The Hearing
Institute which will be associated with a dedicated clinical center, also aims to
develop innovative therapeutic approaches (from engineering solutions to
pharmaceutical and biological agents) to hearing and balance disorders.
The Hearing Institute and the nearby Vision Institute will form a campus at the
cutting edge in basic sensory neuroscience and related innovations towards
patients. It will also enjoy close interactions with Institut Pasteur and the Université
Pierre et Marie Curie. The Hearing Institute will house core facilities for
electrophysiology, imaging (cell, sensory organ and brain), biochemistry, molecular and
cellular biology, bioinformatics, genetics and behavior and will have its own animal housing. Sponsored by Bettencourt-
Schueller Foundation and 'Agir pour l’Audition' Foundation and ‘Voir et Entendre’ Foundation, the Hearing Institute will be
run under the auspices of Université Pierre et Marie Curie (UPMC-Paris-Sorbonne Universités), the French National
Institute of Health and Medical Research (INSERM), Institut Pasteur, the French National Center for Scientific Research
(CNRS) and Collège de France. Various funding opportunities are available. Both senior and junior group leader
applications will be considered. Appointments will be made from junior through to senior level, depending on experience.
Preference will be given to ambitious objectives addressing major challenges in the abovementioned fields.
The deadline for applications is January 15th, 2017. PIs selected by the Hearing Institute Scientific Committee will be
contacted directly and invited for interviews in March-April 2017. The Hearing Institute will open in April 2018.
Applications, including:
-A full CV, including a list of publications
-Past and current research achievements (2 pages)
-The research proposal (5 pages)
-Two letters of recommendation
should be sent to Pr. Christine Petit :christine.petit@pasteur.fr, who can also be contacted for additional information
and Patty Manent, Executive Secretary
Français | English
Brain Plasticity
Laboratoire Unit
Plasticité du
Cerveau
CNRS CNRS Paris
- ESPCI UMR 8249
Home | Research | Where to find us | Contacts
Editorial
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NEWS
Job Offer
Three related topics, i.e. neuroplasticity, neuromodulation and applied
The Brain Plasticity Unit, CNRS‑ESPCI Paris,
studies of various neuropathologies, are addressed in this Laboratory by
currently comprises 5 teams and hosts 50 (...)
an integrated multidisciplinary approach combining genetics, molecular
and cellular biology, advanced imaging methods, electrophysiology and
> More news...
behaviour tests. Complementary neurobiological models are being
studied, from the single neuron to fly and mammalian integrated circuits.Top
The insertion of the Laboratory in the ESPCI ParisTech campus allows
fruitful exchanges between neurobiologists and other scientists, all the
more since experienced physics scientists or students, who are
acquainted with both scientific fields, are present in our laboratory.
Français | English
Brain Plasticity
Laboratoire Unit
Plasticité du
Cerveau
CNRS CNRS Paris
- ESPCI UMR 8249
Home | Research | Where to find us | Contacts
Editorial
Job Offer
About the Laboratory
Junior group leader
The ability to learn, i.e. to alter behaviour according to previous experience, is certainly one
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(such as Atip-Avenir) and a French institutional research position.
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NEWS
Job Offer
For more information:
The Brain Plasticity Unit, CNRS‑ESPCI Paris,
https://www.bio.espci.fr/-Home-
currently comprises 5 teams and hosts 50 (...)
https://www.espci.fr/en/
> More news...
Top
Junior group leader The Brain Plasticity Unit, CNRS-‐ESPCI Paris, currently comprises 5 teams and hosts 50 scientists, students, and staff. The Unit is headed by Thomas Preat. Our work focuses on understanding brain plasticity in physiological conditions and in various neuropathologies. We carry out highly collaborative and multi-‐disciplinary studies using a variety of model organisms. The insertion of the Brain Plasticity Unit in the ESPCI campus, which enjoys a strong culture of scientific excellence (6 Nobel prizes), allows fruitful exchanges between neurobiologists and other scientists including physicists. We are seeking to recruit a junior group leader. Applicants who develop an integrated physiological approach, such as studies combining molecular genetics and functional brain imaging, will be considered in priority. Candidates must hold a French institutional research position (CNRS, INSERM etc.), or they must meet criteria to obtain a French starting grant (such as Atip-‐Avenir) and a French institutional research position. Women are encouraged to apply. Interested candidates should send a full CV, a brief description of their research achievements and of their projects, and a personal statement, to Thomas Preat via email: thomas.preat@espci.fr There is no specific deadline for the application because the selection process will be ongoing in 2016 until a successful candidate has been identified. For more information: https://www.bio.espci.fr/-‐Home-‐ https://www.espci.fr/en/
Institut des Neurosciences Cellulaires & Intégratives
CNRS UPR-3212 - Strasbourg, France
http://inci.u-strasbg.fr/fr/index.html
International Call for New Group Leaders
INCI is a leading French biological Research Center, affiliated to CNRS and the University of Strasbourg
with 9 independent research groups focusing their activity on three priority axes:
- Communication and networks in the nervous system deciphering the mechanisms involved in
neurotransmission and neuroendocrine secretion (exocytosis, endocytosis, membrane fusion), and the
physiology of neural networks (circuits and information in the cerebellar cortex and olfactory);
- Nociception and pain interested in nociceptive signaling mechanisms in the spinal cord, chronic pain
(anatomo-functional approach and treatments), molecular determinants of pain in the brain and
comorbidities of pain;
- Neurobiology of rhythms focusing on rhythms and pathologies in the retina, regulation of circadian clocks
in the central nervous system, melatonin and seasonal rhythms and sleep regulations.
INCI will recruit outstanding scientists addressing biological questions in line with its priority axes.
The newly recruited group will benefit from the expertise and state-of-the-art facilities of the INCI Institute
in molecular biology (quantitative PCR, laser micro-dissection, genomics, optogenetics, transgenic mice),
proteomics (HPLC-MS, flow cytometry, subcellular fractionation), in vitro and in vivo electrophysiology
(ionic currents, synaptic signals), cell imaging (confocal and bi-photonic microscopy, time-lapse, calcium
imaging, bioluminescence), ultrastructure imaging (electron transmission and scanning microscopy),
anatomy (tracing of neural pathways, stereotaxic lesions), in vivo functional exploration (behavioral tests
using animal models for anxiety, pain and depression, cerebral micro-dialysis on freely moving animals,
actimetry and telemetry, sleep rhythm recordings). Appropriate laboratory and office space, depending on
group size, will be available to the selected group leader(s). The candidates must meet criteria to compete
for national and international research funding (ATIP/Avenir Program, FRM Jeune Equipe, ERC Starting
Grant) and for French institutional research and/or teaching positions (CNRS, University).
Applications should include :
- INCI: Ressources humaines au 1er janvier 2014
CV (1-2 pages);
- List of publications, patent applications, invited conferences, awards and grants;
- Description (2-3 pages) of the research project;
- Two letters of reference.
Applications or further inquiries should be sent to Marie-France Bader (badermf@inci-
cnrs.unistra.fr) or Michel Barrot (mbarrot@inci-cnrs.unistra.fr - Tel : 03 88 45 66 33)CALL for NEW RESEARCH GROUP LEADERS, CLERMONT-FERRAND, FRANCE
Deadline ……..July 1st 2017
The Genetics, Reproduction and Development (GReD) laboratory (www.gred-clermont.fr)
is a multi-disciplinary CNRS-INSERM-University research institute on the medical
campus of the University Clermont-Auvergne (35,000 students) the main university in
central France, localised in the lively city of Clermont-Ferrand, with attractive living
conditions and peaceful natural environment.
The GReD consists of 13 groups with research interests ranging from genome dynamics
and epigenetic control, development and stem cell biology to endocrinology and cancer.
Teams use Arabidopsis, Drosophila and mice as models to address questions of
fundamental biology and their application to human health and well-being.
Successful candidates will have access to office and lab space for a team to up to 10
persons in a brand-new 4500 m2 building. The GReD laboratory offers access to state-of-
the-art core services, including up-to date cell imaging and histology platforms, single cell
genomic technologies, transgenic animal (mouse, Drosophila) and plant facilities.
Facilities for high-throughput sequencing, mass spectrometry, proteomics, FACS sorting,
electron microscopy and radiobiology are available on the multidisciplinary Medical
School campus.
We open two distinct calls:
1. Non-thematic call. Open call for group leaders addressing cutting-edge scientific
biological questions, with a special focus on model organism-based research falling
within the scientific missions of the Institute.
2. Systems biology / bioinformatics. We are seeking to recruit a group focusing on
whole genome data analysis, gene regulatory networks or modelling of biological
processes in order to strengthen GReD’s expertise in this fast growing field.
We encourage both young and already established outstanding researchers to apply.
Applications (in English, specifying the call reference as the subject of the email) should
include a curriculum vitae a short description of achievements and a record of self-
financing, accompanied by the proposed research program and contact details for 3
professional references. The deadline for applications is July 1st 2017. Selected
applicants will be interviewed in October 2017. Please send your application as a single
PDF file of approximately 6/10 pages named LASTNAME_GReD_2017.pdf to
direction.gred@udamail.fr. Any enquiries should also be sent to this address.CHEMICAL BIOLOGY
JUNIOR GROUP LEADER POSITION
Institut Curie –Paris, France 26, rue d’Ulm
75248 Paris Cedex 05
Institut Curie (http://www.curie.fr) is constituted of a hospital and a world-class multidisciplinary
research center combining research in cell biology, genetics, epigenetics, immunology, soft matter
physics, organic and medicinal chemistry. It includes over 3,000 researchers, physicians, clinicians,
technicians and administrative staff working on three sites: Paris, Orsay and Saint-Cloud. The institute
facilities include advanced imaging, high throughput sequencing, bioinformatics, small molecule
collection, reverse phase protein array, proteomics and mass spectrometry, antibody technologies,
cytometry, and animal housing (https://science.institut-curie.org/platforms/). In addition, the proximity
with the hospital allows access to large clinical databases and sample collections.
As part of one of its strategic research domain entitled “Multiscale Physics-Biology-Chemistry”, Institut
Curie is supporting the recruitment of an outstanding chemical biologist as Junior Group Leader in the
Chemical Biology of Membranes and Therapeutic Delivery unit (UMR3666 CNRS — U1143
INSERM; http://chemicalbiology.curie.fr) on its research site in central Paris located in an exceptional
scientific environment within PSL University.
The newly recruited group leader will benefit from the expertise of this unit in cell biology, chemical
biology, organic synthesis, and supramolecular chemistry, and from state-of-the-art research equipment.
Appropriate laboratory space for 6-8 people and a start-up package will be available. Successful
candidates should meet criteria to obtain national and international funding, and for French institutional
research positions (CNRS or Inserm).
Applications must comprise a personal statement explaining why you are interested in joining Institut
Curie, a 3-4 page research plan, a full CV detailing publications, patents, invited conferences, awards,
grants, training and teaching experience, and contact details of 3-5 individuals who can be contacted for
recommendation letters. Send these material to Ludger Johannes at ludger.johannes@curie.fr.
Deadline for applications: December 15, 2016
Short-listed candidates will be informed by January 15, 2017, and invited to the Curie Institute by
mid-February 2017Post DOC POSITION
Ecole Polytechnique - University Paris-Saclay
PI: Alexis GAUTREAU alexis.gautreau@polytechnique.edu
https://portail.polytechnique.edu/bioc/en/gautreau
OFFER For PHD or Post Doctoral POSITION
Isolation of novel tumor suppressor genes
that monitor the actin cytoskeleton
Polymerization of branched actin by the Arp2/3 complex drives membrane protrusion
during cell migration. In this process, the Arp2/3 complex is activated by the WAVE complex
and inhibited by Arpin, which we have recently discovered. In most invasive tumors in the
breast, there is either up-regulation of the WAVE complex or down-regulation of Arpin.
These alterations are associated with a poor prognosis for breast cancer patients. We have
shown that this signaling pathway controls cell migration and proliferation in a coordinated
manner. To identify the genes that monitor the actin cytoskeleton, we have performed a
genome-wide RNAi screen and found about 15 potential tumor suppressor genes, which allow
cells arrested in their cell cycle by Arp2/3 inhibition to resume cell cycle progression. The
goal of this PhD is to validate some of these candidates.
To this end, the student will perform a secondary screen by obtaining KO of these genes
in an immortalized human breast cell line or a breast tumor cell line, using the CRISPR-Cas9
technology. The positive hits that transform the immortalized line and renders the tumor cell
line invasive will be further studied. We will address the localization of these tumor
suppressor genes and their cellular function. We expect the hits to localize to the branched
actin networks of membrane protrusions and to regulate cell migration. We will look for
protein partners of the hits using proteomics in order to understand how they perform their
function and how they are regulated.
5 representative publications of the group:
• Lomakina ME, Lallemand F, […], Bièche I, Alexandrova AY, Gautreau A. 2016. Arpin down-
regulation in breast cancer is associated with poor prognosis. Brit J Cancer 114 :145-63.
• Gorelik R, Gautreau A. 2015. The Arp2/3 inhibitory protein Arpin induces cell turning by pausing
cell migration. Cytoskeleton 72:362-71.
• Krause M, Gautreau A. 2014. Steering cell migration: lamellipodium dynamics and the regulation of
directional persistence. Nature Review Mol Cell Biol 15:577-90.
• Gorelik R, Gautreau A. 2014. Quantitative and unbiased analysis of directional persistence in cell
migration. Nature Protocols 9:1931-43.
• Dang I, Gorelik R, Sousa-Blin C, […], Faix J, Blanchoin L, Gautreau A. 2013. Inhibitory signalling
to the Arp2/3 complex steers cell migration. Nature 503:281-4.! !
A post-doctoral position is available for up to 2.5 years in the laboratory of Anne Blangy, at
the CRBM in Montpellier – France, starting March 1rst, 2017:
"Actin and microtubule cross-talk in cell adhesion".
The project aims to investigate actin and microtubule crosstalk in cell adhesion, using the
osteoclast as a model system. The bone resorption apparatus of osteoclast is a unique adhesion
structure made of a belt of densely packed podosomes sustained by a dense network of actin
cables and microtubules. Our aim is to understand the molecular architecture and signaling
pathways among this complex structure, which confers to the osteoclast its unique ability to
degrade the bone. The post holder will use a variety of advanced imaging technics - including
super-resolution microscopy, live cell microscopy and automated imaging – cytoskeleton
signaling approaches and functional bone resorption assays.
The Cell Biology Research Center of Montpellier (CRBM, http://www.crbm.cnrs.fr) is a
dynamic research institute internationally recognized for its basic research in cell biology. It is
located in a new building in Montpellier (South of France) on a multidisciplinary campus of the
French National Center for Scientific Research (CNRS). Research at the institute covers
fundamental and translational aspects of biology, with specific focus on cell signaling and
cytoskeleton dynamics, cell cycle regulation, gene regulation and systems biology of evolution
and molecular biophysics and structural bioinformatics. The CRBM imaging facility is part of
Montpellier RIO Imaging platform with access to the latest technologies in microscopy,
including confocal, spinning disk, 3D-SIM and automated imaging.
The successful candidate will have a PhD in Life Science and have a strong experience in the
cell biology of the cytoskeleton. Good skill in fluorescence imaging, in particular super-
resolution approaches, will be particularly appreciated.
For additional information please contact Anne Blangy (anne.blangy@crbm.cnrs.fr)
Selection of recent publications:
- Touaitahuata H. et al., J Cell Sci. 2016 Sep 15;129(18):3449-61.
- Vives V, Cres G, et al., Nat Commun. 2015 Feb 3;6:6218
- Touaitahuata H. et al., Dev Biol. 2014 Sep 1;393(1):57-70.Christophe LAMAZE, PharmD, PhD
Ins2tut Curie, Paris France
UMR 3666 CNRS / U1143 INSERM
Team “Membrane Dynamics and Mechanics of Intracellular Signaling”
Keywords: caveolae, high resolu2on imaging, mechanobiology, cancer, 3D models
2 YEARS- FUNDED POSTDOC POSITION:
Exploring Caveolae-Mediated Mechanotransduc2on in Cancer
A postdoctoral fellow posi0on is immediately available at the “Membrane Dynamics and
Mechanics of Intracellular Signaling” Team at the Curie Ins0tute in Paris (France).
The project is at the crossroads of cell biophysics and cancer-related
mechanotransduc0on. It aims at iden0fying the molecular mechanisms by which caveolae
mediate the cell response to mechanical stress (Sinha et al., 2011 Cell). We will
inves0gate how caveolae mechanical flaNening controls pro- or an0-cancer signaling
responses through the sensing of the mechanical forces present during tumor mass
evolu0on in breast cancer and melanoma. The present project is part of a collabora0ve
program that integrates cell biology, signaling proteomics, 3D-tumor models (alginate
capsules), high resolu0on imaging (fluorescence correla0on spectroscopy, intravital and
correla0ve in vivo microscopy), mechanical stress devices and forces measurements. The
successful candidate will be a highly mo0vated person, with good communica0on skills
and a solid background in cell biology and/or biophysics. Ideally, s/he will have used cell
imaging techniques during his/her Ph.D. work. Knowledge in membrane trafficking will be
an advantage. Interested candidates should send an email with curriculum vitae,
statement of research interest and names of three references to:
christophe.lamaze@curie.fr. More info @ hNps://science.ins0tut-curie.org/team-lamaze Poten2al roles of caveolae flaVening
Recent publica2ons: in mechanosignaling. (Nassoy and Lamaze, TCB 2012).
1. Blouin et all.,( 2016). Glycosyla0on-Dependent IFN-gammaR Par00oning in Lipid and Ac0n Nanodomains
Is Cri0cal for JAK Ac0va0on Cell 166:920-34.
2. Lamaze, C., and Torrino, S. (2015). Caveolae and Cancer: A New Mechanical Perspec0ve. Biomedical
journal 38, 367-379.
3. Alessandri et al. (2013). Cellular capsules as a tool for mul0cellular spheroid produc0on and for
inves0ga0ng the mechanics of tumor progression in vitro. Proc Natl Acad Sci U S A 110, 14843-14848.
4. Sinha et al., 2011. Cells respond to mechanical stress by rapid disassembly of caveolae. Cell. 144:402-13.Post-doctoral position in Toulouse, France
Consequences of regulatory T cell-recirculation to the thymus
We are seeking a highly motivated and dynamic young scientist for a
post-doctoral position in the ‘T cell-mediated immune tolerance’
laboratory (www.immune-tolerance.fr) headed by Prof. Joost van
Meerwijk at the ‘Center of Pathophysiology of Toulouse Purpan’ (CPTP),
Toulouse, France. The position, financed by the ANR, is available
starting spring 2017 for one year with the possibility of renewal.
Our research focuses on the biology of regulatory T lymphocytes (Treg),
from their development in the thymus to their pre-clinical application for
the induction of transplantation-tolerance (e.g. Joffre et al., Nature
Medicine 2008). We have recently shown that the development of
regulatory T cells is controlled by a negative feedback loop exerted by
peripheral Treg reentering the thymus and inhibiting the differentiation of
their precursors (Thiault et al., Nature Immunol. 2015). The goal of the
project the successful candidate will work on is to determine the
consequences of Treg recirculation on T cell repertoire selection in the
thymus and on susceptibility to autoimmune pathology.
The applicant must have shown research abilities and capabilities to
perform a collaborative project within a team, and possesses good written
and verbal communication skills in English. Applicants must have
training and research-experience in molecular biology, gene expression
analysis, and bioinformatics (generation of libraries, RNA sequencing
and analysis of high throughput sequencing data). Our Center offers a
stimulatory intellectual and collaborative environment and well-equipped
core facilities. Applicants should e-mail before January 1st 2017 their
motivation letter, CV, and contact information of two references with
whom they have worked to: Joost.van-Meerwijk@inserm.fr and
Paola.Romagnoli@inserm.frMechanotransduction associated with integrin-mediated phagocytosis
Institut Cochin, Paris, France
Phagocytosis is the mechanism of internalization of large particles of several microns
in size and therefore, as other cellular functions dealing with large scales, it involves
important mechanical constraints (Niedergang Encyclopedia of Cell Biology 2016,
Marion Dev Cell 2012, Dumas J Cell Biol 2015, Marie-Anaïs Traffic 2016, Marie-
Anaïs J Vis Exp 2016).
The project focuses on the integrins’ family of cell adhesion receptors that signal
through the plasma membrane in both directions. We propose to investigate actin-
binding proteins, and their associated regulators, as mechanosensitive hubs at the
center of feedback loops that control anchoring to the actin cytoskeleton and
activation of the integrins during phagocytosis in macrophages.
The objectives of the project are to dissect the mechanisms by which
mechanosensitive protein machineries sense force and modulate actin dynamics
and anchoring during CR3-mediated phagocytosis.
The team “Biology of Phagocytes” is part of the “Infection, Immunity and
Inflammation” Department at Institut Cochin. Institut Cochin is a large research centre
that provides multidisciplinary environment and exquisite technology platforms.
The project is led in collaboration with Christophe Le Clainche (Ciobanasu Eur J Cell
Biol 2013, Nat Comm 2014, Nat Protoc 2014), who developed a new microscopy
assay to reconstitute and characterise actomyosin-dependent mechanosensitive
machineries with pure proteins on geometrically-defined micropatterned surfaces.
We are seeking a motivated candidate with a PhD, preferably in cell biology and/or
biophysics. Background in microscopy, exposure to live-cell imaging, mathematical
modeling and biophysical methods are desirable.
Contract : two years.
Interested applicants should contact Florence Niedergang with a CV and name of
references.
Florence Niedergang, Team Biology of Phagocytes
Institut Cochin (Inserm U1016, CNRS UMR8104, Université Paris Descartes)
22, rue Méchain, 75014 Paris, France
Email : Florence.Niedergang@inserm.fr; Tel : 33(1) 40 51 64 21
website: http://cochin.inserm.fr/Departements/ih/equipe-niedergang/
http://NiedergangLab.free.frPost-‐doc
in
Reproductive
Biology
–
IBPS
PARIS
We
are
looking
for
a
postdoctoral
candidate
to
work
on
mitochondrial
inheritance.
We
are
interested
in
understanding
the
cell
and
developmental
mechanisms
of
uniparental
and
maternal
mitochondrial
genome
inheritance.
The
lab
is
currently
investigating
how
sperm
mitochondria
are
targeted
for
degradation
and
how
maternal
contribution
remains
homoplasmic
throughout
generations.
We
are
using
live
imaging
and
genetic
screens
on
C.
elegans
to
tackle
these
two
fundamental
questions.
Financing
for
this
postdoc
is
available
initially
for
12
months
with
the
possibility
for
renewal.
Our
group
is
part
of
the
IBPS
(Institut
de
Biologie
Paris-‐Seine)
in
the
Department
of
Developmental
Biology.
Our
Institute
is
located
on
the
campus
of
University
Pierre
and
Marie
Curie
in
the
heart
of
Paris.
State-‐of-‐the-‐Art
imaging
equipment
is
available
in
the
lab
and
in
the
facility.
The
candidate
is
expected
to
be
a
PhD,
with
no
or
max.
2
years
of
postdoctoral
experience
and
with
a
solid
background
in
Cell
Biology/Molecular
Biology.
Experience
with
live
cell
imaging
will
be
an
advantage.
He/she
should
be
interested
in
reproduction
and
mitochondrial
inheritance.
The
candidate
should
be
fluent
in
English,
and
is
expected
to
have
obtained/obtain
at
least
one
first
author
publication
in
a
peer-‐reviewed
journal
from
his/her
PhD
work.
lnterested
candidates
should
send
their
CV
including
research
interests
and
contact
details
of
two
referees
in
a
single
pdf
file
to
vincent.galy@upmc.fr.
Priority
will
be
given
to
applications
received
before
September
15th,
but
the
position
will
remain
open
until
a
suitable
candidate
has
been
found.
Cel-‐HD
team
(http://dev-‐nematode.snv.jussieu.fr/)
University
Pierre
et
Marie
Curie,
UMR
CNRS
7622,
Laboratory
of
Developmental
Biology
9
quai
Saint-‐Bernard,
75252
PARIS
Cedex
05,
France
Institute
of
Biology
Paris-‐Seine
vincent.galy@upmc.fr
/
phone
:
(33)
(0)1
44
27
34
94
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